Unlocking Perioperative Neurocognitive Disorders: From Risk to Resilience

Have you ever wondered about the potential impact of surgery and anesthesia on cognitive function? Today’s show will discuss the complexities of Perioperative Neurocognitive Disorders (PND), a term encompassing conditions like postoperative delirium (POD), postoperative cognitive decline (POCD), and delayed neurocognitive recovery (DNR).

Through insightful discussions rooted in the latest research, we aim to shed light on:

• The prevalence and impact of PND, drawing from studies highlighting its occurrence after various surgical procedures.
• Potential risk factors that may make individuals more susceptible to developing PND.
• Innovative approaches for prevention and management, including the investigation of medications like dexmedetomidine and anesthetic techniques such as total intravenous anesthesia (TIVA) with propofol, which some studies suggest may have neuroprotective properties.
• The intricate underlying mechanisms of PND, exploring the roles of neuroinflammation, oxidative stress, and even insulin signaling in the central nervous system.
• The use of monitoring techniques like electroencephalography (EEG) to better understand and potentially mitigate neurocognitive complications.
• The importance of early identification and comprehensive care for individuals experiencing PND.

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